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  1. Agoff SN, Lin P, Morihara J, et al. p16INK4a expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Modern Pathol. 2003;16:665-73.
  2. Bergeron C, Ordi J, Schmidt D, Trunk MJ, Keller T, Ridder R. Conjunctive p16INK4a testing significantly increases accuracy in diagnosing high-grade cervical intraepithelial neoplasia. Am J Clin Pathol., in press
  3. Brown DC, Gatter KC. Ki-67 protein: the immaculate deception? Histopathology 2002;40:2-11.
  4. Carozzi F, Confortini M, Del Mistro A, et al. p16INK4a expression as an adjunctive marker in cervical specimens of HR-HPV-positive women in a screening setting. Cancer Cytopathol. 2006;108:119-23.
  5. Carozzi F, Confortini M, Dalla Palma P, et al. Use of p16INK4a over-expression to increase the specificity of human papillomavirus testing: a nested substudy of the NTCC randomised controlled trial. Lancet Oncol. 2008;9:937-45. 6. Chen SF, Yang SF, Chu TY, et al. Which test is a better strategy to determine the outcome of atypical glandular cell-categorized Pap smears? Immunocytochemical p16INK4a expression or human papillomavirus test - a retrospective cohort study. Gynecol Oncol. 2005;99:578-84.
  6. Christal L, Valente T. The utility of p16 immunohistochemistry in the diagnosis of cervical intraepithelial neoplasia. Pathology Case Reviews 2006;11:117.
  7. Cuschieri K, Wentzensen N. Human papillomavirus mRNA and p16 detection as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev. 2008;17:2536-45.
  8. Del Pino M, Garcia S, Fusté V, et al. Value of p16INK4a as a marker of progression/ regression in cervical intraepithelial neoplasia grade 1. Am J Obstet Gynecol. 2009;201.
  9. Guo M, Hu L, Baliga M, et al. The predictive value of p16INK4a and hybrid capture 2 human papillomavirus testing for high-grade cervical intraepithelial neoplasia. Am J Clin Pathol. 2004;122:894-901.
  10. Gurrol-Díaz CM, Suárez-Rincón AE, Vázquez-Camacho G, et al. p16INK4a immunohistochemistry improves the reproducibility of the histological diagnosis of cervical intraepithelial neoplasia in cone biopsies. Gynecol Oncol. 2008;111:120-4.
  11. Hariri J, Oster A. The negative predictive value of p16INK4a to assess the outcome of cervical intraepithelial neoplasia 1 in the uterine cervix. Int J Gynecol Pathol. 2007;26:223-8.
  12. Holladay EB, Logan S, Arnold J, et al. A comparison of the clinical utility of p16INK4a immunolocalization with the presence of human papillomavirus by hybrid capture 2 for the detection of cervical dysplasia/neoplasia. Cancer Cytopathol. 2006;108:451-61.
  13. Horn LC, Reichert A, Oster A, et al. Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histological diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2008;32:502-12.
  14. Ishikawa M, Fujii T, Saito M, et al. Overexpression of p16INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer 2006;16:347-53.
  15. Klaes R, Friedrich T, Spitkovsky D, et al. Overexpression of p16INK4a as a specific marker for dysplasia and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276-84.
  16. Klaes R, Benner A, Friedrich T, et al. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol. 2002; 26:1389-99.
  17. Meyer JL, Hanlon DW, Andersen BT, et al. Evaluation of p16INK4a expression in ThinPrep cervical specimens with the CINtec p16INK4a assay. Cancer Cytopathol. 2007;111:83-92.
  18. Mulvany NJ, Allen DG, Wilson SM. Diagnostic utility of p16INK4a: a reappraisal of its use in cervical biopsies. Pathology 2008;40:335-44.
  19. Negri G, Egarter-Vigl E, Kasal A, et al. p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immuncytochemical correlations. Am J Surg Pathol. 2003; 27:187-93.
  20. Negri G, Vittadello F, Romano F, et al. p16INK4a expression and progression risk of lowgrade intraepithelial neoplasia of the cervix uteri. Virchows Arch. 2004;445:616-20.
  21. Nieh S, Chen SF, Chu TY, et al. Is p16INK4a expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undertemined significance-categorized Pap smears? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol. 2005;97:35-40.
  22. Ordi J, Garcia S, del Pino M, et al. p16INK4a immunostaining identifies occult CIN lesions in HPV-positive women. Int J Gynecol Pathol. 2008;28:90-7.
  23. Redman R, Rufforny I, Liu C, et al. The utility of p16INK4a in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix. Arch Pathol Lab Med. 2008;132:795-9.
  24. Sano T, Oyama T, Kashiwabara K, et al. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol. 1998 ;153:1741-8.
  25. Sayed K, Korourian S, Ellison DA, et al. Diagnosing cervical biopsies in adolescents: the use of p16 immunohistochemistry to improve reliability and reproducibility. J Lower Genital Tract Dis. 2007;11:141-6.
  26. Schlederman D, Andersen BT, Bisgaard K, et al. Are adjunctive markers useful in routine cervical cancer screening? Application of p16INK4a and HPV-PCR on ThinPrep samples with histological follow-up. Diagn Cytopathol. 2008;36:453-9.
  27. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000;182:311-22.
  28. Schorge JO, Lea JS, Elias KJ, et al. p16INK4a as molecular biomarker of cervical adenocarcinoma. Am J Obstet Gynecol. 2004;190:668-73.
  29. Szarewski A, Ambroisine L, Cadman L, et al. Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears. Cancer Epidemiol Biomarkers Prev. 2008;17:3033-42.
  30. Trunk MJ, Dallenbach-Hellweg G, Ridder R, et al. Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples. Acta Cytol. 2004;48:771-82.
  31. von Knebel Doeberitz M. New markers for cervical dysplasia to visualise the genomic chaos created by aberrant oncogenic papillomavirus infections. Eur J Cancer. 2002; 38:2229-42.
  32. Wang SS, Trunk M, Schiffman M, et al. Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev. 2004;13:1355-60.
  33. Wentzensen N, Bergeron C, Cas F, et al. Evaluation of a nuclear score for p16INK4a– stained cervical squamous cells in liquid-based cytology samples. Cancer Cytopathol. 2005;105:461-7.
  34. Wentzensen N, Bergeron C, Cas F, et al. Triage of women with ASCUS and LSIL cytology. Use of qualitative assessment of p16INK4a positive cells to identify patients with high-grade cervical intraepithelial neoplasia. Cancer Cytopathol. 2007;111:58-66.
  35. Wentzensen N, von Knebel Doeberitz M. Biomarkers in cervical cancer screening. Dis Markers. 2007;23:315-30. 37. Yoshida T, Fukuda T, Sano T, et al. Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing: a comparative study using simultaneously sampled histology materials. Cancer Cytopathol. 2004;102:100-8.



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